Vesicle Transport: A Close Collaboration of Rabs and Effectors
نویسنده
چکیده
COPII vesicles transport proteins destined for secretion from the ER to the Golgi apparatus. A recent study has shown that, in budding yeast, the formation of COPII vesicles requires Yip1p, an effector protein of a Rab GTPase.
منابع مشابه
Rab GTPases in the formation of transport vesicles and in their motor protein-dependent movement on cytoskeletal tracks from sites of formation to sites of fusion
Rab GTPases and their effectors regulate membrane traffic by determining, along with cognate SNAREs, the specificity of transport vesicle docking and fusion steps. Recent studies have also implicated Rabs in the movement of these transport vesicles from their site of formation to their site of fusion, and several Rabs have been linked to specific microtubuleor actin-based motor proteins. Analys...
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The Rab family of small GTPases serves as cellular regulators of vesicular transport in all eukaryotes. Higher organisms have a vastly expanded number of Rabs. Some of these would presumably perform cell-type or tissue-specific functions. Roles for Rab proteins in several aspects of cellular physiology that are peculiar to neurons have been revealed. Rabs, in conjunction with their effectors an...
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Rab proteins constitute the largest branch of the Ras GTPase superfamily. Rabs use the guanine nucleotide-dependent switch mechanism common to the superfamily to regulate each of the four major steps in membrane traffic: vesicle budding, vesicle delivery, vesicle tethering, and fusion of the vesicle membrane with that of the target compartment. These different tasks are carried out by a diverse...
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The Rab family of small GTP-binding proteins has long been implicated in the docking and fusion of transport vesicles with their target membranes. Recent evidence, however, suggests that some Rabs may play an additional role in transport vesicle formation.
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BACKGROUND INFORMATION The pathology causing stages of the human malaria parasite Plasmodium falciparum reside within red blood cells that are devoid of any regulated transport system. The parasite, therefore, is entirely responsible for mediating vesicular transport within itself and in the infected erythrocyte cytoplasm, and it does so in part via its family of 11 Rab GTPases. Putative functi...
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ورودعنوان ژورنال:
- Current Biology
دوره 14 شماره
صفحات -
تاریخ انتشار 2004